CV

Education

Medical Scientist Training Program (MD-PhD), Stanford University School of Medicine (‘22-‘30)

BS in Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles (12/20)

• Summa Cum Laude and Departmental Honors

• Departmental Honors Thesis: A Systems-Level Analysis of Common Variable Immunodeficiency

Research

• Butte Lab
  Undergraduate Researcher

  February 2018-April 2022

  Common Variable Immunodeficiency

  • Utilized Cytometry by Time of Flight (CyTOF) as a methodology to establish functional cellular differences in patients with CVID
  • Optimized assay to measure phospho-protein levels in immunodeficiency patients
  • Creating a novel 2-component Gaussian Mixture Model methodology to analyze CyTOF signaling data
  • Making machine learning models to correlate signaling, exome data with clinical phenotype in CVID

  Candidate Variants for Inborn Errors of Immunity

  • Utilized the OmniPath meta-database to find variants functionally related to known IEI genes
  • Produced comprehensive list of IEI-related genes for novel IEI gene discovery in the clinic
  • Creating an R Shiny Webapp to functionalize variants filtering for clinicians

  Adducin and CD4 T Cell Costimulation

  • Utilized confocal microscopy and ImageJ to link the actin capping protein Alpha-Adducin to CD4 T-cell costimulation
  • Used R to fit logistic regression curves for dose-responsive T-cell proliferation curves

  Basophil Activation Test

  • Worked to optimize a high-throughput assay to diagnose allergy
  • Mentored a high school student in the summer of 2018

• Bruins in Genomics Summer Research Fellowship
  Undergraduate Researcher

  June 2020-Present

  • Received $4,000 stipend to fund and continue data science work on CVID
  • Presented at the Systems Biology journal club
  • Created novel SIR model for COVID-19 Forecasting Hackathon

Volunteering and Service

• TheXperiment

  Mentor, Marketing Chair (‘18-‘19), Treasurer (‘19-‘20), and Post-Grad Advisor (‘20-‘21)

  June 2017-Present

  • Personally mentored 30+ underserved children one-on-one in scientific topics of their interests
  • Garnered over $10,000 in funding for students’ projects and club maintenance
  • Coordinated three city-wide science fairs
  • Revamped organization website
  • Coordinated site visits of 75+ mentors and 100+ mentees

• Assessing Residents’ CI-CARE

  Volunteer (‘17-‘19) and General Surgery/Urology Department Lead (‘19-‘20)

  September 2017-June 2020

  • Surveyed General Surgery and Head and Neck Surgery patients for satisfaction with their residents
  • Spearheaded a project to increase efficiency by digitizing surveying
  • Led a group of five volunteers to analyze data to assess resident physician communication scores
  • Affiliated as organization photographer, research associate, social media director, and website editor

• Irvington High School Alumni Mentor

  September 2018-Present

  • Guiding students of my former high school with extracurriculars, college admissions, and life advice
  • Gave talk to parents regarding supporting their children during the admissions cycle

Skills

• R
  • Libraries: tidyverse (purrr, ggplot2, dplyr), resample, ggbiplot, mixtools
  • Some experience in package development
• ImageJ/Fiji
  • Experience developing macros for data processing
  • Comfortable with image analysis
• Python
  • Beginner skill level
• C++
  • Beginner skill level

Publications

Khan HA, Acar U, Thauland TJ, Stephens AV, Butte MJ. Complicated Common Variable Immunodeficiency is Driven by Aberrant IL-10/IL-21 Signaling and Predisposed Polygenic Risk. medRxiv. https://doi.org/10.1101/2022.06.20.22276681.

Aron JL, Thauland TJ, Khan HA, Butte MJ. Humanized mice bearing CRISPR/Cas9 Disruption of Signal Transducer and Activator of Transcription 1 (STAT1) to Model Primary Immunodeficiency. bioRxiv. https://doi.org/10.1101/2022.06.20.496920.

Khan HA, Butte MJ (2021). Expanding the Potential Genes of Inborn Errors of Immunity through Protein Interactions. BMC Genomics 22, 618 (2021). https://doi.org/10.1186/ s12864-021-07909-3.

Thauland TJ, Khan HA, Butte MJ (2019). The Actin-Capping Protein Alpha-Adducin Is Required for T-Cell Costimulation. Front. Immunol. 10:2706. Link.

Posters and Abstracts

Khan HA, Thauland TJ, Garcia AJ, Butte MJ (2020). A Signaling and Phenotypic Analysis of Common Variable Immunodeficiency Patients through Mass Cytometry. Journal of Clinical Immunology. Supplement 1:S1 40 –S163. Link.

Khan HA, Thauland TJ, Garcia AJ, Butte MJ. A Signaling and Phenotypic Analysis of Common Variable Immunodeficiency Patients through Mass Cytometry. Presented at MIMG Undergraduate Research Symposium; 2019 December 6; Los Angeles, Ca.

Ru K, Khan H, Neman S, Faith J, Moseley T, Dubey I, Ratnaparki, R, Lu O, Gonzalez L. Comparing ACGME Core Competency Scores Between 1st and 3rd year Internal Medicine Residents at UCLA Health. Poster presented at UCLA Undergraduate Research Poster Day; 2019 May 21; Los Angeles, Ca.

Soohoo A, Khan H, Cevallos N, Hankerson B, Lu O, Kim J, Gonzalez L, Mosley V. An Assessment of Communication and Professionalism of Medical Residents at the Ronald Reagan UCLA Medical Center from 2015 to 2017. Poster presented at UCLA Undergraduate Research Poster Day; 2018 May 22; Los Angeles, Ca.

Awards

• Association of Biomedical Research Undergraduate Research Grant
  • Inaugural grant given on the basis of commitment to research
  • Funded summer research of 2019
• UCLA Chancellor’s Service Award
  • Given to graduating students with an extraordinary commitment to service
• UCLA Dean’s Honor List
  • All quarters

• UCLA BIG Summer COVID-19 Hackathon Winner

• BIG Summer Research Excellence Award

Relevant Coursework

Undergraduate MIMG Coursework

• Nuclear Cell Biology, Biochemistry I, Microbiology, Virology, Microbial Genomics, Bioethics, Scientific Communication I/II, Immunology

Graduate Dual-Enrolled Classes

• Advanced Immunology, Algorithms in Bioinformatics